冠心病患者金属硫蛋白2A基因多态性与冠状动脉病变程度的相关性

摘要

目的 研究冠心病(CHD)患者金属硫蛋白2A(MT2A)基因-838G/C多态性与冠状动脉病变程度的关系.方法 采用单荧光标记探针技术检测278例CHD患者的MT2A基因838G/C多态性,应用冠状动脉病变支数和SYNTAX积分表示冠状动脉病变程度.结果 CHD患者中,C等位基因(GC+CC基因型)携带者的SYNTAX积分明显高于非C等位基因(GG基因型)携带者(P＜o.05),不同冠状动脉病变支数间的基因型分布差异有统计学意义(P＜0.05).冠状动脉病变支数和SYNTAX积分与GC+ CC基因型呈显著正相关(r=0.282和r=0.135,P＜0.05).结论 CHD患者MT2A基因838G/C多态性与冠状动脉病变程度存在相关性.%Objective To investigate the association of-838G/C polymorphism in the metallothionein 2A(MT2A) gene and the severity of coronary artery stenosis in the patients with coronary heart disease(CHD).Methods The genotypes of-838G/C polymorphism in the MT2A gene were detected by single-labeled probe technique in 278 patients with CHD,the severity of coronary artery stenosis was characterized by the numbers of diseased coronary vessels and SYNTAX scores.Results SYNTAX scores of patients with C allele carriers(GC+CC genotype) were obviously higher than those with non-C allele carriers(GG genotype)(P＜0.05),ard the distribution of genotypes was statistically different among variable numbers of diseased coronary vessels(P＜0.05).The number of diseased coronary vessels and SYNTAX scores were positively correlated with GC+CC genotype (r=0.282 and r=0.135,P＜0.05).Conclusion The MT2A-838G/C polymorphism is closely associated with the severity of coronary artery stenosis in the patients with CHD.