食管鳞癌组织中CD44v6与E-钙黏蛋白表达及其临床意义

摘要

目的 探讨食管鳞癌组织CD44v6与E-钙黏蛋白(E-cad)表达与其临床病理特征的关系.方法 采用免疫组化法检测48例食管鳞癌(A组)、23例糜烂性食管炎(B组)和24例正常食管黏膜组织(C组)CD44v6和E-cad的表达,分析其表达与食管鳞癌临床病理特征的关系.结果 A组CD44v6表达明显高于B、C组,而E-cad表达明显低于B、C组(P＜0.05).CD44v6和E-cad的表达与食管鳞癌浸润深度和淋巴结转移密切相关(P＜0.05).食管鳞癌组织中CD44v6和E-cad表达水平呈负相关(r=-0.580,P＜0.05).结论 联合检测病变组织中CD44v6与E-cad的表达有望成为食管鳞癌筛查及预后判断的辅助指标.%Objective To investigate the expression and clinical significance of CD44v6 and E-cadherin in the esophageal squamous cell carcinoma. Methods With immunohistochemistry, the expressions of CD44v6 and E-cadherin were detected in 48 esophageal squamous carcinoma tissues (group A),23 erosive esophagitis tissues(group B) and 24 normal esophagus tissues(group C). The relationship of the expressions of CD44v6 and E-cadherin and clinicopathological characteristics of esophageal squamous cell carcinoma were analyzed. Results Compared to groups of B and C, the expression of CD44v6 was higher, but that of E-cadherin was lower, in group A(P<0. 05). The expressions of CD44v6 and E-cadherin were closely related to the depth of invasion and the status of lymph node metastasis of esophageal squamous cell carcinoma (P<0. 05). The expression level of CD44v6 was negatively correlated with that of E-cadherin in group A (r=-0.580, P<0. 05). Conclusion Combined detection of CD44v6 and E-cadherin in diseased tissues is hopeful as the adjutant indicators in screening and predicting the prognosis of esophageal squamous cell carcinoma.