Argonaute1 rs636832 A＞G基因多态性和食管癌淋巴结转移危险因素的关系

摘要

Objective To explore the influence of argonautel rs636832 A>G polymorphism on esophageal cancer lymphatic metastases in Chinese Han population. Methods Genotypes were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method in 85 lymphatic metastasis positive patients(group A) and 270 lymphatic metastasis negative patients(group B). The association between argonautel genotypes and the risk for esophageal cancer lymphatic metastasis was calculaed by computing the odds ratio (OR) and 95% confidence interval(CI). Results The frequency of argonautel rs636832 A>G was not significantly different between groups of A and B. logistic analysis showed that compared to the individuals carrying argonautel rs636832 AA gene,carrying argonautel rs636832 GG allelic genotype was not significantly correlated to the risk for esophageal cancer lymphatic metastases(OR=0. 69,95% CI = 0. 25-1. 92). Conclusion Argonautel rs636832 A>G genotype may not be significantly associated with a risk for esophageal cancer lymphatic metastases.%目的 探讨中国汉族人群argonaute1 rs636832 A＞G基因多态性对食管癌淋巴结转移危险因素的影响.方法 采用以医院为基础的病例-病例研究方法,基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)技术分析380例食管癌argonaute1 rs636832 A＞G基因多态性,计算各种基因型的食管癌淋巴结转移风险及其95％可信区间.结果 食管癌淋巴结转移组和无转移组argonaute1 rs636832 A＞G多态性位点频率无明显差异.Logistic回归显示,与携带argonaute1 rs636832AA基因型的个体相比较,携带argonaute1 rs636832GG等位基因型与食管癌淋巴结转移风险无明显相关(OR=0.69,95％CI=0.25-1.92).结论 Argonaute1 rs636832 A＞G基因多态性可能与食管癌淋巴结转移无明显相关.