克林霉素致不良反应的分析

摘要

目的 探讨克林霉素的不良反应发生规律及特点,为临床安全用药提供参考.方法 对最近5年来国内102篇克林霉素致不良反应文献报道进行整理,分类统计和分析.就不良反应的临床表现、严重不良反应发生的机制以及克林霉素临床用药的安全性进行分析探讨.结果 有139例147次不良反应,病例涉及12个器官或系统损害,前3位依次是过敏反应、泌尿系统损害和神经系统损害.结论 临床应重视克林霉素引起的严重的不良反应,严格适应证,了解患者既往过敏史及合并用药的品种等;应防止剂量过大,静脉滴速过快和疗程过长,同时在用药过程应中加强监护.%Objective To discuss the general regularity and the characteristics of the adverse reaction of Clindamycin and provide security references for clinical application.Methods To analyse and discuss the clinical manifestations of adverse reactions,serious adverse events,and the clinical application of Clindamycin security with classification statistics and analysis of 102 domestic literature reports about adverse reactions of Clindamycin for the past 5 years.Results 139 cases of adverse reactions in 147 times, involving 12 kinds organ or system damage, the top three were allergic reactions, urinary system damage and damage to the nervous system.Conclusions It should pay attention to serious adverse reactions of Clindamycin, strict indications, understand the patients allergic history and drug combination; It should prevent excessive doses,fluid drop too fast and too long in intravenous treatment,and intensive care in the course of medication.