0bjective To explore the diagnostic value of proton magnetic resonance spectroscopy ( 1H-MRS ) in schizophrenia. Methods Using point resolved acquisition mode, 26 schizophrenia patients and 25 healthy subjects underwent MRS examination nn the left and right frontal, hippocampus and thalamus. The metabolites of MRS including N-acetyl aspartate ( NAA ), creatine ( Cr ), and chohne ( Cho ) were analyzed and compared between the two groups. Results NAA/Cr in the left and right frontal, hippocampus, and thalamus was 1.41 ± 0.33, 1.40 ± 0.36, 1.43 ± 0.27, 1.42 ± 0.26,1.46 ± 0.30, and 1.45 ± 0.28, respectively in schizophrenia patients, which was lower than those in the healthy subjects, but with no significant difference ( P＞ 0.05 ), Cho/Cr was 1.36 ± 0.38, 1.37 ± 0.29,1.30 ± 0.31, 1.31 ± 0.28, 1.20 ± 0.20, and 1.22 ± 0.19, respectively, which was higher than those in the healthy subjects, whereas with no significant difference ( P＞ 0.05 ), NAA/( Cho+Cr ) was 0.60 ± 0.14, 0.61 ± 0.16, 0.62 ± 0.20, 0.63 ± 0.23, 0.66 ± 0.18, and 0.66 ± 0.21, respectively, which was lower than those in healthy subjects, with a significant difference ( P ＜ 0.05 ). In schizophrenia patients, the levels of NAA/Cr, NAA/( Cho+Cr ) decreased and Cho/Cr increased in the order of frontal to hippocampus and then to thalamus. Conclusions A decline in NAA and a rise in Cho are the main demonstration on MRS for schizophrenia patients, which plays a role in the diagnosis of schizophrenia.%目的 探讨质子磁共振波谱( 1H-MRS)在精神分裂症中的诊断价值。方法 采用点分辨解析采样方式对26例精神分裂症患者和25例健康志愿者的左右侧额叶、海马和丘脑行MRS检查，分析的代谢产物有N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)及相互间比值在两组间的差别。结果 精神分裂症患者在左额叶、右额叶、左海马、右海马、左丘脑和右丘脑的NAA/Cr分别为1.41±0.33、1.40±0.36、1.43±0.27、1.42±0.26、1.46±0.30、1.45±0.28，低于健康组对应位置，但差异无统计学意义(P＞0.05)；Cho/Cr分别为1.36±0.38、1.37±0.29、1.30±0.31、1.31±0.28、1.20±0.20、1.22±0.19，高于健康组对应位置，但差异无统计学意义(P＞ 0.05)；NAA/( Cho+Cr)分别为0.60±0.14、0.61±0.16、0.62±0.20、0.63±0.23、0.66±0.18、0.66±0.21，明显低于健康组对应位置，且二组差异有统计学意义（P＜ 0.05）。精神分裂症患者NAA/Cr、NAA/( Cho+Cr)的下降幅度和Cho/Cr的上升幅度，额叶＞海马＞丘脑。结论 精神分裂症患者MRS改变，主要体现在NAA的下降和Cho的上升，对精神分裂症的诊断有一定的参考作用。
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