血浆BNP水平在ST段抬高急性心肌梗死静脉溶栓中的临床意义

摘要

目的 检测急性心肌梗死患者溶栓前后血浆BNP,探讨其变化特点及临床意义.方法 60例患者分A组(未溶栓,18例),B组(溶栓未通,11例)和C组(溶栓再通,31例),测定入院即刻,发病24小时和5天血浆BNP,进行组内和组间比较.结果 三组发病24小时和5天BNP均高于入院即刻(P＜ 0.05),A及B组发病24小时和5天BNP比较差异无显著性(P＞0.05),C组发病5天BNP低于发病24小时(P＜0.05),三组入院即刻BNP比较差异无显著性(P＞0.05).A和B组之间发病24小时以及5天的BNP比较差异无显著性(P＞0.05),但两组均相应高于C组(P＜0.05).结论 动态检测STEMI患者溶栓前后血浆BNP,有利于观察溶栓疗效、从而为病情评估、进一步治疗及预后判断提供依据.%Objective Brain natriuretic peptide (BNP) before and after thrombolysis in the patients with ST-elevated myocardial infarction(STEMI) were measured to explore their change characteristics and clinical significance.Methods 60 patients with a first ST -elevated myocardial infarction were divided into three groups :A group (non- thrombolysis n=18), B g-roup (non- reperfusion n=11) and C group (reperfusion n=31).the serum BNP at the hospitalized time,on24th hour and on the 5th day after ons-et of AMI wered measured with a immmunofluorescence assay provided by Triage Biosite, and then the consequences were compared between and in the groups. Results in the three groups :The levels of serum BN-P on the 24th hour and the 5th day were higher than those at the hos-pitalized time (P＜ 0.05), In the A and B groups,the serum BNP levels on the 5th day I were not different from those on 24th hour ,but in the -C group ,The levels of serum BNP on the 5th day were decreased sig-niticantly (P＜ 0.05) .between the groups: there are no diference in the the serum BNP levels at the hospitalized time.between the A and B grou-ps, the serum BNP levels both on the 24th hour and on the 5thday w-ere not diferent,but the serum BNP levels on the 24th hour and the 5th day of the two groups were higher than those of the reperfusion group(P＜ 0.05), Conclusion BNP measureme nt may help us evaluate the effi-cacy of thrombolysis,so it can offer evidence for assessing their condition, further treatment and the prognosis of AMI.