Objective To investigate the change rule of serum levels of C-reactive protein and liver and kidney function in pregnancy induced hypertension syndrome (PIH) patients and its clinical significance.Methods 96 cases of PIH (50 cases of mild PIH,46 cases of severe PIH) and 50 cases of normal pregnant women (control group) were collected to detect CRP,Alb,ALT,AST,GGT,ALP,Urea,UA,Cr by automatic biochemical analyzer.The result was statistically analyzed.Results The serum level of CRP in PIH patients was higher than that in control group (P ＜ 0.01),the serum level of CRP in severe PIH patients was obviously higher than that in mild PIH patients (P ＜ 0.01).The serum levels of Alb in two PIH groups were lower than that in control group (P ＜ 0.05),the serum level of Alb in severe PIH group was obviously lower than that in mild PIH group (P ＜ 0.05).The serum levels of ALT,AST,GGT,ALP,Urea,UA and Cr in PIH patients were higher than those in control group (P ＜ 0.05),the serum levels of UA and Cr in severe PIH patients were higher than those in mild PIH patients (P ＜ 0.05),there were no significant differences in ALT,AST,GGT,ALP and Urea between two PIH groups (P ＞ 0.05).Conclusions The serum level of CRP is higher in PIH patients,associated with the severity of the illness.The liver and kidney function in PIH patients are damaged.The serum level of UA rises significantly,which can be a good monitoring indicator of PIH condition.%目的 探讨妊娠高血压综合征(妊高征,PIH)患者血清C-反应蛋白和肝、肾功能的变化规律及其临床意义.方法 选择96例PIH患者(PIH轻度组50例、PIH重度组46例)和50例孕晚期的正常孕妇(对照组)作为观察对象,采用全自动生化分析仪检测所有孕妇的血清C-反应蛋白(CRP)、白蛋白(Alb)、丙氨酸氨基转移酶(ALT)、天门冬氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、尿素(Urea)、尿酸(UA)、肌酐(Cr),并对结果进行统计学分析.结果 PIH患者血清CRP水平明显高于对照组孕妇(P＜0.01),且PIH重度组患者明显高于轻度组(P＜0.01).两组PIH患者血清Alb含量均较对照组孕妇明显降低,差异具有统计学意义(P＜0.05),且PIH重度组患者明显低于轻度组(P＜0.05)；PIH患者血清ALT、AST、GGT、ALP和Urea、UA、Cr水平均较对照组孕妇显著升高,差异具有统计学意义(P均＜ 0.05)；PIH重度组患者血清UA和Cr水平明显高于轻度组(P＜0.05),两组PIH患者之间血清ALT、AST、GGT、ALP和Urea水平差异无统计学意义(P＞0.05).结论 PIH患者的血清CRP水平升高,与病情的严重程度相关；PIH患者肝、肾功能均受损；血清UA水平随病情加重升幅明显,可作为PIH病情监测的较好指标.
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