2型糖尿病并发严重下肢动脉阻塞性病变的相关因素分析

摘要

目的 总结2型糖尿病并发严重下肢动脉阻塞性病变的相关危险因素.方法 将340例2型糖尿病患者按照是否有并发严重下肢动脉阻塞性病变分为观察组(并发下肢动脉阻塞性病变)110例和对照组(无下肢动脉阻塞性病变)230例.记录两组患者年龄、病程、有无高血压史、体重指数、血压(收缩压和舒张压)、总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、尿酸、糖化血红蛋白(HbA1C),并使用SPSS进行单因素和逻辑斯蒂多因素回归分析,以总结2型糖尿病并发严重下肢动脉阻塞性病变的危险因素.结果 单因素分析结果表明:性别比、年龄、病程、吸烟史、高血压史、HbA1C、三酰甘油、尿酸和踝臂指数是诱发严重下肢动脉阻塞性病变的危险因素(P＜0.05).多因素回归分析表明:性别、年龄、病程、高血压史、HbA1C、三酰甘油、尿酸是导致2型糖尿病并发严重下肢动脉阻塞性病变的主要原因(P＜0.05).结论 对男性老年患者积极控制血糖、血压、高尿酸和三酰甘油可以较好预防2型糖尿病并发严重下肢动脉阻塞性病变的发生.%Objective To summarize related risk factors of type 2 diabetes with severe lower extremity arterial occlusive disease through statistical analysis.Methods 330 patients with type 2 diabetes,according to whether there was concurrent severe lower extremity arterial occlusive disease,were divided into observation group (110 cases) and control group (230 cases).Observation group was complicated by peripheral arterial obstructive disease group,the control group was no lower extremity arterial occlusive disease group.We recorded the indexes of patients as follows:age,disease duration,with or without a history of hypertension,body mass index,blood pressure (systolic and diastolic),total cholesterol,triglycerides,low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C),uric acid,glycosylated hemoglobin (HbA1C),and used SPSS univariate and multivariate logistic regression analysis to summarize type 2 diabetes with severe lower extremity arterial occlusive disease risk factors.Results Univariate analysis showed that sex ratio,age,duration,smoking history,history of hypertension,HbA1C,triglycerides,uric acid,and ankle-brachial index were induced in the observation group risk factors (P ＜ 0.05).Multivariate analysis showed that gender,age,disease duration,history of hypertension,HbA1C,triglycerides,uric acid were the main causes of type 2 diabetes with severe lower extremity arterial occlusive disease (P ＜ 0.05).Conclusion The elderly male patients with active control of blood glucose,blood pressure,high uric acid and triglycerides can better prevent type 2 diabetes with severe lower extremity arterial occlusive disease from occurring.