产妇血清表面抗原定量与乳汁中乙肝病毒载量的相关性分析

摘要

目的 探讨携带乙型肝炎病毒(HBV)的产妇血清表面抗原(HBsAg)含量与乳汁中HBV-DNA含量的相关性,并指导母乳喂养.方法 对140例产妇采用荧光定量PCR法测定乳汁中HBV-DNA和化学发光法测定表面抗原含量,并进行相关性分析.结果 A组乳汁HBV-DNA阳性组表面抗原含量为(58 183.2±39 147.8) IU/ml,B组HBV-DNA阴性组表面抗原含量为(1848.8±2458.3) IU/ml.A组血清中表面抗原含量比B组高,差异有统计学意义(P＜0.01),乳汁中HBV-DNA含量与血清中表面抗原含量呈正相关(r=0.799,P＜0.01).结论 慢性HBV感染孕产妇血清中乙肝表面抗原的定量的测定及检测其乳汁中HBV-DNA含量,对阻断母婴传播和预防家庭内水平传播及对HBV感染孕产妇的诊治和疗效评估有着重要意义,特别是为HBV感染产妇选择是否母乳喂养提供了指导依据.%Objective To explore the correlation between the serum HBsAg and HBV-DNA level in the milk of postparum women with hepatitis B and then to research whether breast feeding is safe or not and who is ready for breast feeding.Methods 140 postparum women with hepatitis B were chosen from our hospital.Their serum HBsAg level and HBV-DNA level in milk after child-birth were detected.The correlation was analyzed.Results The serum HBsAg level was (58 183.2 ± 39 147.8)IU/ml in the women positive in HBV-DNA in milk and was (1848.8 ± 2458.3)IU/ml in the women negative in HBV-DNA in milk,with a statistical difference(P＜0.01).The serum HBsAg level positively correlated with HBV-DNA level in milk(r=0.799,P＜0.01).Conclusions Detecting the serum HBsAg level and HBV-DNA level in milk of HBV-infectious postparum women has clinical significance for these women's diagnosis and treatment and the treatment effect evaluation and can provide some guidelines for breast-feeding.