速尿联合多巴胺治疗急性肾炎伴急性肾功能衰竭的临床研究

摘要

Objective To investigate the clinical effect of furosemide combined with dopamine in the treatment of acute nephritis(AGN) complicated with acute renal failure(ARF).Methods 98 patients with AGN complicated with ARF treated at our hospital firom June,2013 to March,2016 were selected and randomly divided into a control group and an observation group.The control group were routinely and comprehensively treated;in addition,the observation group were treated with furosemide and dopamine.The clinical efficacy,urinary protein (PRO),blood urea nitrogen(BUN),times recovering to normal,hospital stay,and urinary protein quantitation,BUN,serum creatinine (SCr) levels and other renal function indicators before and 24 h after the treatment were compared between these two groups.Results The total effective rate was 93.88％ in the observation group and was 77.55％ in the control group (P＜0.05).The time for PRO and BUN recovering to normal and hospital stay were significantly shorter in the observation group than in the control group (P＜0.01).,The levels of urinary protein,BUN,and SCr were significantly lower 24 h after than before the treatment in both groups (P＜0.01);and the improvement degree of the observation group was more significant (P＜0.01).Conclusions Furosemide combined with dopamine in the treatment AGN complicated with ARFT is prominently effective and can effectively curb the development of ARF and recover the patients' renal function,so it has certain clinical reference value.%目的 探讨急性肾炎(AGN)伴急性肾功能衰竭(ARF)患者应用速尿联合多巴胺治疗的临床效果.方法 选取本院2013年6月至2016年3月收治的98例AGN伴ARF患者,随机均分为两组.对照组给予常规综合治疗;观察组在对照组基础上给予速尿联合多巴胺治疗.比较两组临床疗效,尿蛋白(PRO)、血尿素氮(BUN)恢复正常时间及住院时间,治疗前后24h尿蛋白定量、BUN及血肌酐(SCr)水平等肾功能指标.结果 观察组总有效率为93.88％,明显高于对照组的77.55％(P＜0.05);观察组PRO、BUN恢复正常时间和住院时间均显著短于对照组(P＜0.01);两组治疗后24h尿蛋白定量、BUN及SCr水平与治疗前比较,均显著降低(P＜0.01),但观察组的改善程度更为显著(P＜0.01).结论 AGN伴ARF应用速尿联合多巴胺治疗效果突出,能有效遏制ARF病情发展,快速恢复肾功能,具有一定临床参考价值.