速尿与多巴胺联合治疗急性肾炎伴急性肾功能衰竭的临床观察

摘要

目的 探讨速尿与多巴胺联合治疗急性肾炎(AGN)伴急性肾功能衰竭(ARF)的临床疗效.方法 90例AGN伴ARF患者按随机数字表法分为观察组和对照组,每组45例.对照组给予常规治疗,观察组在此基础上联合应用速尿和多巴胺.结果 观察组总有效率为93.3%(42/45),对照组为75.6%(22/45),差异有统计学意义(P<0.05);治疗后两组肌酐(SCr)、尿素氮(BUN)、24 h尿蛋白量水平均较治疗前显著下降(P<0.05),观察组较对照组下降更为显著(P<0.05);观察组BUN、尿蛋白恢复正常时间及住院时间均显著短于对照组(P<0.05).结论 速尿与多巴胺联合治疗AGN伴ARF能显著提高疗效,迅速改善肾功能,值得临床推广应用.%Objective To investigate the clinical efficacy of Furosemide combined with Dopamine in the treatment of acute glomerulonephritis (AGN) with acute renal failure (ARF). Methods 90 cases with AGN and ARF according to random number table were divided into the observation group and the control group, with 45 cases in each group. The control group received conventional therapy, the observation group were given the Furosemideand Dopamine on the basis of control group. Results The total effective rate of observation group was 93.3% (42/45), the control group was 75.6% (22/45), the difference was statistically significant (P ＜ 0.05); after treatment, the SCr and BUN, 24 h urinary protein of two groups were decreased significantly than those pre-treatment (P ＜ 0.05), which in the observation group they were decreased more significantly than that of control group (P ＜ 0.05); BUN and urinary protein recovery time and the hospital stay time of the observation group were significantly shorter than those of control group (P ＜ 0.05). Conclusion The Furosemide combined Dopamine in the treatment of AGN with ARF can significantly improve the efficacy, rapidly improve the renal function, which is worthy of clinical application.