帕罗西汀联合针刺治疗难治性强迫症的对照研究

摘要

Objective To explore the efficacy and safety of acupuncture in the treatment of refractory obsessive-compulsive disorder (ROCD).Methods 60 patients with ROCD were randomly divided into a study group (n=30,acupuncture combined with paroxetine 40-60 mg/d) and a control group (n=30,paroxetine 40-60 mg/d).Both groups were treated for 8 weeks.The efficacy was assessed with Yale-Brown obsessive-compulsive scale(Y-BOCS) and Hamilton depression scale(HAMD).The side effects were assessed with treatment emergent symptom scale(TESS).Results The overall effective rate was significantly higher in the study groupthan in the control group (80.0％ vs.66.7％,P＜0.05).The scores of YBOCS and HAMD decreased more in the study group than in the control group (P＜0.01).There were no statistical differences in TESS between the study group and the control group (P＞0.05).Conclusions Acupuncture combined with paroxetine for patients with ROCD is effective and safe.%目的 探讨针刺治疗难治性强迫症患者的临床效果和安全性.方法 将60例难治性强迫症患者随机分为研究组(帕罗西汀+针刺,n=30)和对照组(帕罗西汀,n=30)进行治疗,疗程为8周.采用耶鲁-布朗强迫症状评定量表(Y-BOCS)、汉密尔顿抑郁量表(HAMD)评价两组疗效;采用副作用量表(TESS)评价两组安全性.结果 研究组和对照组有效率分别为80.0％和66.7％,差异有统计学意义(P＜0.05);治疗后,研究组Y-BOCS、HAMD评分下降更明显(P＜0.01);两组在治疗过程中出现的副作用比较,差异无统计学意义(P＞0.05).结论 针刺合并帕罗西汀治疗难治性强迫症可提高疗效,且安全性好,值得进一步推广应用.