丙戊酸钠联合拉莫三嗪治疗不同类型儿童癫痫的临床对比

摘要

Objective To observe the clinical effect of sodium valproate combined with lamotrigine for children with different types of epilepsy.Methods 127 epileptic children treated at our hospital were selected and were divided into a PS (partial seizure) group (52 cases),an SGS (secondary generalized seizure) group (37cases),a GS group (generalized seizure)(28 cases),and an LGS (Lennox Gastaut syndrome) group (10 cases)according epileptic types.All the patients were treated with sodium valproate and lamotrigine.The clinical effect of each group was observed.Results The complete control rate of the SGS group (35.14％) was significantly higher than those of the other groups (P＜0.05).The complete control rate of the LGS group (0.00％) was lowest.The total effective rate of the SGS group (64.86％) was significantly higher than those of the other groups (P＜0.05).The total effective rate of the LGS group (30.00％) was lowest.After treatment,the attack frequency decreased in all groups,with statistical differences (P＜0.05).Conclusions Sodium valproate combined with lamotrigine has a distinguishable effect in children with different types of epilepsy,can greatly reduce the attack frequency of epilepsy.It has the highest effect in the SGS group.%目的 观察丙戊酸钠联合拉莫三嗪治疗不同类型儿童癫痫的临床效果.方法 选取本院收治的儿童癫痫患者127例,根据癫痫类型分为部分发作型(PS)组(52例)、部分发作继发全面发作(SGS)组(37例)、全面性发作(GS)组(28例)和Lennox Gastaut综合征(LGS)组(10例).所有患者均给予丙戊酸钠联合拉莫三嗪治疗,观察各组临床治疗效果.结果 SGS组完全控制率为35.14％,明显高于其他3组(P＜ 0.05);LGS组全控制率最低,为0.00％.SGS组治疗总有效率为64.86％,明显高于其他3组(P＜0.05);LGS组治疗总有效率最低,为30.00％.与治疗前比较,各组发作频次均有不同程度减少,差异均有统计学意义(P＜0.05).结论 丙戊酸钠联合拉莫三嗪治疗不同类型儿童癫痫均有不同程度的效果,均能够显著减少患儿癫痫发作次数,其中以SGS疗效最为明显.