布洛芬在全身炎症反应综合征治疗中对血清降钙素原的影响分析

摘要

Objective To study the regulating effect of ibuprofen on serum procalcitonin (PCT) in the treatment of systemic inflammatory response syndrome (SIRS).Methods 250 cases of SIRS in our hospital from January 2012 to January 2015 were collected,and randomly divided into observation group and control group.124 cases in control group were only treated with antibiotic,and 126 cases in observation group were given ibuprofen nasogastric treatment.Serum PCT level before and after administration and under different critically ill degrees were compared,at the same time body temperature recovery time,WBC count returning to normal time and total cure time were recorded.Results ① There was no statistically significant difference in serum PCT level between two groups before administration (P＞0.05);after administration,serum PCT level of observation group was significantly lower than that of control group (P＜0.05).② There was no statistically significant difference in serum PCT level between children whose critically ill degree was ＜80 points of two groups (P＞0.05);serum PCT level of children whose critically ill degree was ≥80 points of observation group was significantly lower than that of control group (P＜0.05).③ Body temperature recovery time,WBC count returning to normal time and total cure time of observation group were significantly shorter than those of control group (P＜0.05).Conclusions Ibuprofen in the treatment of children with SIRS has ideal effect,which can effectively reduce serum PCT level of children especially for children with mild degree,and promote the recovery as soon as possible,is suitable for clinical promotion.%目的 研讨全身炎症反应综合征患儿运用布洛芬治疗对其血清降钙素原(PCT)的调节作用.方法 我院2012年1月至2015年1月共收集250例全身炎症反应综合征病例资料,依照随机分配法分组,对照组124例单纯予抗生素治疗,观察组126例选择布洛芬鼻饲治疗,对比两组给药前后及不同危重程度下的血清PCT变化情况,同时记录其体温恢复时间、白细胞计数恢复正常时间和总治愈时间.结果 ①给药前,两组的血清PCT值比较基本相当,无统计学差异(P＞0.05),给药后,观察组的PCT值相比对照组明显降低,有统计学差异(P＜0.05).②两组危重程度＜ 80分患儿的血清PCT值基本相似,无统计学差异(P＞ 0.05),危重程度≥80分的比较,观察组的血清PCT值相比对照组明显更低,有统计学差异(P＜ 0.05).③与对照组相比,观察组的体温和白细胞计数恢复明显更快,总治愈时间明显更短,有统计学差异(P＜0.05).结论 对全身炎症反应综合征患儿实施布洛芬治疗具有较理想的效果,可有效降低患儿特别是轻微程度患儿的血清降钙素原水平,促进其尽早恢复,适合在临床推广.