MIC-1、OPN及CA19-9联合检测在诊断胰腺癌患者中的应用价值

摘要

目的 探讨血清巨噬细胞抑制因子1(MIC-1)、骨桥蛋白(OPN)及糖类抗原19-9(CA19-9)联合检测在诊断胰腺癌患者中的应用价值.方法 纳入60例健康者为对照组与63例胰腺癌患者为观察组进行研究,均收集血清进行MIC-1、OPN及CA19-9水平检测.结果 对两组的血清MIC-1、OPN、CA19-9水平进行检测和比较,对照组的上述指标水平分别为(485.12±75.23) pg/ml、(35.12±15.12) ng/ml、(26.34±2.47) U/ml,均显著低于观察组的(1 559.15±225.16)pg/ml、(115.25±35.23)ng/ml、(195.12±18.25)U/ml,(t=15.21、8.15、9.12,P＜ 0.05).3种指标单独检测,以MIC-1检测的敏感性最高,显著高于其他2项指标(x2=5.12、6.03,P＜0.05),其他2项指标差异无统计学意义(P＞0.05).CA19-9检测的特异性最高,显著高于其他2项指标(x 2=5.88、5.75,P＜0.05),其他2项指标差异无统计学意义(P＞0.05).3种检测方法的准确性基本相当,差异均无统计学意义(均P＞ 0.05),MIC-1+OPN+CA19-9检测的敏感性和特异性以及准确性均显著高于3项指标单独检测的水平,差异均有统计学意义(均P＜0.05).结论 胰腺癌诊断中实施MIC-1、OPN及CA19-9联合检测可以获得更好的检测结果,显著提高检测的准确性等,具有一定的临床应用价值.%Objective To explore the application value of serum macrophage inhibitory factor 1 (MIC-1),osteopontin (OPN),and carbohydrate antigen 19-9 (CA19-9) combined detection in the diagnosis of pancreatic cancer patients.Method 60 healthy persons and 63 cases of pancreatic cancer were collected for serum MIC-1,OPN,and CA19-9 levels detection in the study.Results Serum MIC-1,OPN,and CA19-9 levels in the control group were respectively (485.12±75.23)pg/ml,(35.12±15.12)ng/ml,(26.34±2.47)U/ml,significantly lower than those in the observation group [(1 559.15±225.16)pg/ml,(115.25±35.23)ng/ml,(195.12± 18.25)U/ml] (t=15.21,8.15,9.12;P＜0.05).MIC-1 single detection showed the highest sensitivity,significantly higher than that of the other two indexes (x 2=5.12,6.03;P＜0.05),without statistically significant difference between the other two indexes (P＞0.05).CA19-9 single detection showed the highest specificity,significantly higher than that of the other two indexes (x 2=5.88,5.75;P＜0.05),without statistically significant difference between the other two indexes (P＞0.05).The accuracy of the three methods were quite similar (P＞0.05).The sensitivity,specificity,accuracy of MIC-1,OPN,and CA 19-9 combined detection were significantly higher than those of single detection of the three indexes (P＜0.05).Conclusion MIC-1,OPN,and CA19-9 combined detection can obtain better results in the diagnosis of pancreatic cancer,significantly improve the accuracy of detection,with certain clinical application value.