乙肝病毒携带产妇血清、乳汁HBV-DNA检测及母乳喂养安全性临床研究

摘要

目的 研究乙肝病毒携带产妇母乳喂养的安全性.方法 收集192例乙肝病毒携带产妇静脉血、乳汁,检测血清和乳汁的HBV-DNA载量,并对已进行规范免疫的婴儿的乙肝病毒携带情况进行追踪检测.结果 血清、乳汁HBV-DNA阳性率均是“大三阳”产妇最高, “小三阳”产妇次之, “单阳”产妇最低.三类产妇乳汁HBV-DNA阳性率差异有统计学意义(x2=5.99,P＜0.05),母乳喂养组与人工喂养组婴儿血清HBsAg阳性率差异有统计学意义(x2=6.33,P＜0.05).结论 在规范完成乙肝母婴传播性阻断措施的前提下,同时检测产妇的血清和乳汁,HBV-DNA载量在一定范围内,乙肝病毒携带产妇母乳喂养是安全的.%Objective To study the security of breast feeding in hepatitis B virus carrying pregnant women.Methods The venous blood,milk of 192 hepatitis B virus carrying pregnant women were collected,tested the HBV-DNA load in serum,milk,and followed the HBV carrying condition of babies who had been done standard immunization.Results The positive rate of HBV-DNA in serum,milk were the highest in HBeAg + HBeAg + HBcAb positive pregnant women,followed by HBsAg + HBeAb + HBcAb positive pregnant women,the lowest in HBsAg positive pregnant women.There was statistically significant difference in HBV-DNA positive rate in milk among three groups (x2=5.99,P＜0.05).There was statistically significant difference in HBsAg positive rate in babies' serum between breast feeding group and artificial feeding group (x2=6.33,P＜0.05).Conclusion Complete progresses of mother-infant block of HBV in standard,meanwhile test serum,milk of pregnant women,breast feeding of HBV carrying mothers is safe if HBV-DNA load is in a certain range.