目的 探讨血清孕酮及CA125对早期先兆流产研究对象的诊断价值与效能.方法 收集本院2015年9月至2016年1月入院检查并确诊为早期先兆流产者57例,根据妊娠结局分为两组,并收集同期入院检查的48例健康孕妇作为对照组,比较3组研究对象的血清P与CA125水平、分布情况与检验效能.结果 3组研究对象血清P与CA125总体存在较大差异;流产妊娠结局不良组血清P显著低于流产妊娠结局良好组与对照组,CA125显著高于流产妊娠结局良好组与对照组;流产妊娠结局良好组血清P显著低于对照组,CA125显著高于对照组;3组研究对象血清P与CA125的均值、下25％与上75％分位数比较差异均有统计学意义,因此血清P与CA125可作为预测早期先兆流产诊断与妊娠结局的指标;血清P与CA125联合诊断的灵敏度、特异度与诊断符合率最高,误诊率与漏诊率最低.结论 血清孕酮与CA125联合检测对对早期先兆流产的诊断价值明显,检验效能更强,具有可行性.%Objective To investigate diagnostic value and performance of serum progesterone and CA125 in the diagnosis of threatened abortion.Methods 57 women diagnosed with threatened abortion by admission examination at our hospital from,September 2015 to January,2016 were collected as study objects and were divided into two groups according to the pregnancy outcomes.48 healthy women taking physical examination during the same period were set as a control group.The serum levels,distribution,and performance of CA125 and P were compared between these 3 groups.Results There were statistical differences in the serum levels of CA125 and P between these 3 groups.The serum level of P was significantly lower and the level of CA125 was significantly higher in the adverse pregnancy outcome group than in the good pregnancy outcome group and the control group and were so in the good pregnancy outcome group than in the control group.There were statistical differences in the mean levels of CA125 and P and lower 25％ and upper 75％ quantile between these 3 groups,so the serum levels of CA125 and P could diagnose threatened abortion and predict the pregnancy outcomes.The combination of P and CA125 was sensitive and specific and had high diagnostic accuracy and low rates of misdiagnosis and missed diagnosis.Conclusions The combination of serum progesterone and CA125 in the diagnosis of early threatened abortion has high value and performance and is feasible.
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