Objective To evaluate immunogenecity of high hepatitis B vaccine coverage. Methods We analyzed incidence and inoculation data of each year and detected the sero-prevalence by the method of ELISA for HBsAg, Anti-HBs, and Anti-HBc. Serologic results before and after the inoculation were compared to evaluate the effects of vaccine coverage. Results Since twenty years after hepatitis B vaccination (1992-2011), the incidence among children under 15 years old decreased by 86.84%. The peak of incidence among children of 5-14 years old was flattened. Carrier rate of HBsAg decreased from 13.59%in 1990 to 4.61% in 2006. It has fallen from a high popular area to a moderately popular area. Carrier rate of HBsAg among children under 15 years old decreased from 12.67% to 0.82% (decreased by 93.53%). Conclusions There is prominent immune protective effect of hepatitis B vaccine with high coverage, which should be maintained.%目的 评价乙型肝炎(乙肝)疫苗高免疫覆盖率的免疫效果.方法 收集接种人群历年的接种报告、乙肝血清学流行率调查结果,分析乙肝疫苗接种后历年乙肝发病的疫情报告,采用酶联免疫吸附试验测定乙肝表面抗原、乙肝表面抗体和乙肝核心抗体,并与接种前期的检测结果进行比较.结果 1992—2011年(乙肝疫苗接种20年)烟台市15岁以下儿童乙肝发病下降了86.84%.5~14岁发病高峰被削平.全人群乙肝表面抗原携带率从1990年13.59%,降至2006年4.61%,从乙肝高度流行区降到了中度流行区.同期0~15岁乙肝表面抗原携带率由12.67%降至0.82%,降幅达到93.53%.结论 乙肝疫苗高覆盖率接种有显著的免疫保护效果,应继续坚持.
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