Oct4及其亚型调控细胞多能性的研究进展

摘要

Reprogramming of somatic cells to embryonic stem cell (ESC)-like induced pluripotent stem cells has been achieved by transfection of the four transcriptions factors (oct4, sox2, c-Myc and klf4). Oct4 is indispensable for reprogramming, and plays important roles in transcriptional regulation, signal transduction, epigenetic modification and so on. By reviewing how Oct4 and its isoforms contribute to pluripotency maintenance in ESC, we show how Oct4 works in pluripotency regulation of cellular reprogramming. Meanwhile, this will help to provide rationale for the researches on stemneas regulation by Oct4 in dental pulp stem cell.%利用oct4、sox2、c-Myc、klf4基因转染体细胞可获得与胚胎干细胞(ESC)类似的诱导性多能干细胞.中,ct4作为体细胞重编程必不可少的核心转录因子,转录调节、信号传导通路、表观遗传修饰等方面具有重要调控作用.文通过阐述Oct4及其亚型调控ESC多能性的作用机制,示其在体细胞重编程中的调节作用,期为研究Oct4对牙髓干细胞的调节作用提供一定的理论依据.