脱细胞异体真皮基质在牙周病学中的应用

摘要

脱细胞异体真皮基质(ADM)是通过物理化学方法处理供体皮肤,脱去其表皮层中所有细胞成分,而获取的结缔组织基质成分,因而ADM保留了细胞外基质的生化特性和三维空间框架结构,具有组织相容性,可用于修复组织缺损及牙周组织再生.ADM作为一种创伤修复材料,被广泛应用于医学领域,已有体外培养、动物实验和临床试验等相关研究,本文将对ADM的材料特性、作用机制以及在牙周病学中的应用作一综述.%Acellular dermal matrix(ADM) is produced by a progress that removed cell component and preserved the dermis,which reserved properties of extracellular matrix and retained structural architecture.With good histocompatibility,ADM could be applied to restore tissue defect and guide tissue regeneration.Studies in vitro,in vivo and clinical trials showed that ADM had been widely used in medicine as a repair material.This review summarized the progress of ADM on the properties,mechanisms and applications in periodontology.