肺动脉高压动物模型研究进展

摘要

Pulmonary hypertension (PH) has become a serious threat to human health.It's the only way to improve disease prevention and control of PH to strengthen the research on the pathogenesis of PH and promote the development of new drugs.Therefore,the establishment of a stable,repeatable,animal pathogenesis and pathophysiological features similar to human disease,and the production of simple animal models is that we take as an important basis for the study of PH.The methods for producing PH models at home and abroad are reviewed in this paper,so that researchers can select suitable animal models according to the research purpose.%肺动脉高压已经成为严重危害人民群众健康的一大类疾病,加强肺动脉高压发病机制研究、推进新型药物研发是提高肺动脉高压防治水平的必经之路.因此,建立稳定、可重复、与人类疾病发病机制及病理生理学特征相似且制作简单的动物模型,是研究肺动脉高压的基础.本文将国内外制作肺动脉高压模型的方法进行综述,以便研究者根据研究目的选择适合的动物模型.