GGH基因多态性与甲氨蝶呤药物敏感性的关系

摘要

γ-谷氨酰水解酶(GGH)是甲氨蝶呤(MTX)聚谷氨酸化的一种关键酶，高水平的GGH与MTX的耐药有关。近来研究发现GGH基因单核苷酸多态性可使该基因表达和催化活性发生改变，导致MTX的细胞毒作用产生个体差异。该文就GGH的结构功能特点及其基因多态性与MTX药物敏感性关系的研究进展进行综述。%Gamma-glutamyl hydrolase (GGH) plays an important role in methotrexate (MTX)polyglutarmation. High level of GGH has been associated with cellular resistance to MTX. Recent studies have demonstrate that some polymorphisms of GGH could change the expression and catalytic activity of the enzyme,causing interindividual difference in MTX cytotoxicity. No study about GGH was reported in Chinese population. This paper reviewed the advances about the structure and function of GGH and its gene, and the advances in associations between polymorphisms of GGH and MTX sensitivity.