破骨细胞和辅助性T细胞

摘要

骨免疫学主要研究T细胞和破骨细胞的互相作用.有研究证实,产生白细胞介素17的辅助性T细胞可诱导核因子κB配体受体活化因子在滑膜细胞上表达,并和炎症细胞因子一起刺激破骨细胞分化和骨质吸收的活性.骨免疫学对抗风湿病药物研发和风湿病治疗有重要意义.%The interaction between T cell and osteoclasts is important in osteoimmunology.T-helper cells,which produce interleukin-17,induce the expression of receptor activator of nuclear factor κB ligand in synovial cells.Companied by with inflammatory cytokines,they stimulate the differentiation and activation of osteoclasts.Osteoimmunology helps us understand how antirheumatic drugs work,as well as developing new therapeutic strategies for rheumatic diseases.