惊厥性脑损伤与细胞自噬的相关性

摘要

自噬是溶酶体降解利用细胞内物质成分的过程,对应激状态下神经细胞存活及清除衰老细胞器和错误折叠蛋白等起重要作用；其可作为神经细胞的保护机制,也可作为神经细胞死亡方式之一.反复惊厥可以导致脑损伤,但具体机制尚不清楚,最近研究表明,惊厥时可启动细胞凋亡途径,并且也可启动细胞自噬,从而介导神经元适应、损伤或凋亡,惊厥性脑损伤与细胞自噬密切相关.细胞自噬作为一条新的重要的信号途径,为惊厥脑损伤的防治提供新的治疗方向.%Autophagy is a lysosomal degradation of intracellular material composition,and plays an important role in nerve cell survival and clear senescent cells and misfolded proteins.Autophagy can protect nerve cells,but also can be used as one of the ways about nerve death.Repeated seizures can cause brain damage,but the specific mechanism is not clear.Recent studies have shown that,convulsion can activate apoptosis pathway and start autophagy,which can mediate the adaptation,injury or apoptosis of neurons.Convulsion brain injury is closely related to cell autophagy.Autophagy as a new important signaling pathway can provide a new therapeutic direction of convulsion brain damage.