Recombinant human growth hormone (rhGH) has been widely used in clinical treatment of growth hormone deficiency(GHD),and has achieved satisfactory effect.Growth hormone (GH) can stimulate liver cells to produce insulin-like growth actor(IGF-1) which mediated GH growth promoting effect.The majority of IGF-1 combine with insulin like growth factor binding protein 3.IGF-1 promotes cell mitotic and inhibit cell apoptosis,in recent years,some scholars have reported that there is a certain relationship between IGF-1 and tumor occurrence and development,and thus leading to the attention to the efficacy and safety of rhGH treatment.%基因重组人生长激素(recombinant human growth hormone,rhGH)已广泛应用于儿科临床治疗生长激素缺乏症,并已取得较满意的疗效.生长激素(growth hormone,GH)通过刺激肝脏细胞产生胰岛素样生长因子(insulin-like growth actor,IGF-1)来介导GH的促生长作用.血浆中大部分IGF-1与胰岛素样生长因子结合蛋白3结合,IGF-1具有促进细胞有丝分裂抑制细胞凋亡的作用,近年来发现IGF-1与肿瘤的发生发展有一定相关性,因而引发了对rhGH治疗的安全性和有效性的关注.
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