非IgE介导食物过敏的诊治

摘要

食物过敏是免疫机制介导的食物不良反应,近年报道其发病率呈现上升趋势.按发病机制将食物过敏粗略分为IgE介导型和非IgE介导型.目前非IgE介导型食物过敏的机制并不明确,临床上也缺乏特异性的诊断手段.非IgE介导型食物过敏多累及消化道,由于症状的非特异性和迟发型,常常导致临床医生的误诊误治.该文根据作者临床实践对非IgE介导型食物过敏的诊治作一介绍.%Food allergy(FA) seems to be increasing world wide which is roughly divided into IgE mediated or non-IgE mediated FA(NFA).NFA primarily affects the gastrointestinal mucosa which is far less understanding the immunological mechanisms than IgE-mediated FA.Clinicians sometimes experienced confusion due to delayed onset of symptoms and subsequent difficulty in making the clinical association between offending food and clinical symptoms.The lack of easily accessible diagnostic measures also contributes to the problem.The diagnosis of NFA usually is established in the eliminated of food allergen and food challenge test.In this paper,the diagnosis and treatment of NFA is introduced combined with our clinical practice experience.