硒对生物健康双向作用的研究进展

摘要

硒是人、动物和某些微生物正常生存所必需的一种非金属微量元素.硒对生物健康具有双向作用,即氧化作用和抗氧化作用.缺硒可能引发免疫系统功能损伤,导致一些病毒感染毒性增强或感染加剧,以及体内谷胱甘肽过氧化物酶活性下降,增加了氧化损伤和病毒基因突变的可能性.硒的安全摄取量范围相对较窄,过量的摄取可能导致中毒.该文就硒对生物健康双向作用的研究进展作一综述.%Selenium, a metalloid mineral micronutrient,is an essential component for the adequate and healthy life of human, animals, and some other microorganisms.Selenium has antioxidative and oxidative effects on living organisms.Selenium deficiency has been associated with impaired function of the immune system.Selenium deficiency appears to enhance the virulence or progression of some viral infections.Selenium deficiency results in decreased activity of glutathione peroxidase, increasing oxidative damage and the likelihood of mutations in the viral genome.The safe range of selenium intake is relatively small and excess selenium intake can readily result in toxicity.This review summarizes the updates of benefitial and adverse effects of selenium on health.