维生素A与儿童支气管哮喘关系的研究进展

摘要

国内外研究表明维生素A与儿童支气管哮喘有关,哮喘患儿普遍存在维生素A缺乏,且患儿体内水平越低,哮喘发作程度越重.动物实验表明,维生素A缺乏可促使哮喘发生和(或)加重哮喘发作,可能与参与免疫调节,维持气道上皮完整性,促进肺的正常发育以及抗氧化作用等有关.但维生素A补充与哮喘的关系仍颇具争议,其在哮喘治疗的作用尚未得到肯定.该文就目前国内外对维生素A与哮喘的相关研究进展作一综述.%Growing research worldwide suggests that vitamin A(VA) plays an important role in asthma.vitamin A deficiency (VAD) could be commonly found in children with asthma.The lower the serum VA concentration is, the more severe the asthma is.In animal experiments, VAD could promote asthma occurrence as well as exacerbation, via regulating T cell function, maintaining airway epithelium integrity, promoting the normal development of lung,antioxidation and so on.However,the effect of vitamin A supplement on asthma is still controversial.