气道平滑肌细胞与哮喘气道重塑

摘要

Asthma is a extensive airway limited disease caused by allergens or other factors and emerging under bronchial hyper-responsiveness,which is a common chronic respiratory disease.Airway inflammation and airway remodeling is the main feature of bronchial asthma,and airway remodeling is the main pathological basis causing the irreversible airflow obstruction and pulmonary function injury of asthma.The main pathological change of airway remodeling is airway smooth muscle layer thickening induced by airway smooth muscle cell (ASMC) proliferation,and the mast and increasing number of ASMC under the action of various cytokines is the main cause of smooth muscle layer thickening.The function of airway smooth muscle cells in the airway remodeling is described.%支气管哮喘是由变应原或其他因素引起的支气管高反应下出现的广泛气道狭窄性疾病,是一种常见的慢性呼吸道疾病.气道炎症和气道重塑是支气管哮喘的主要特征,气道重塑是造成哮喘不可逆性气流阻塞及肺功能损害的主要病理基础.气道重塑的最主要的病理学改变是气道平滑肌细胞增殖所致的气道平滑肌层增厚,在多种细胞因子的共同作用下引起的气道平滑肌细胞的肥大及数目的增加是平滑肌层增厚的重要原因.该文就气道平滑肌细胞在气道重塑中的作用作一综述.