低出生体重与肾脏疾病关系的研究进展

摘要

Newborn due to low birth weight caused by preterm or fetal growth restriction will have an adverse effect on kidney development. In adulthood,the long-term adverse effects of low birth weight are associ-ated with a variety of kidney disease. Current studies suggest that low birth weight may participate in a variety of kidney disease development and progression by affecting the nephron number,the function of the vascular struc-ture and the endocrine level. This paper mainly reviews the relationship between low birth weight and kidney dis-ease.%新生儿由于早产或胎儿生长受限而造成的低出生体重将会对肾脏的发育产生不良影响。在成人期，低出生体重儿的远期不良效应与多种肾脏疾病进展相关。研究提示低出生体重可能通过影响肾单位的发育、微血管结构功能及内分泌水平而参与了多种肾脏疾病的发生和发展。该文主要就低出生体重与肾脏疾病发生的关系做一综述。