发作性睡病是一种慢性睡眠障碍，是一种白天过度嗜睡的重要原因，往往伴有猝倒发作、睡眠瘫痪、睡眠幻觉等其他症状，合称为发作性睡病四联症。该文综述近年来中西医在发作性睡病病因方面的研究进展，为本病发病机制的研究提供进一步的方向。目前，西医主要认为发作性睡病的发病机制与食欲素和HLA-DQB1基因∗0602亚型密切相关，此外，近年来西欧某些国家(英国、芬兰、瑞典)研究还发现， H1 N1流感疫苗的使用导致了发作性睡病发病率明显上升。中医主要认为，阴阳偏盛和营卫运行失常易引起睡眠障碍，同时儿童发作性睡病的病因与脏腑的关系也相当密切。%Narcolepsy is a chronic sleep disorder,and a main cause for excessive daytime sleepiness. It is accompanied by cataplexy,sleep paralysis and sleep hallucinations,collectively known as tetralogy of narcolep-sy. Research progresses in the pathogenesis of narcolepsy are briefly summarized in this article,paving directions for further research. Both the realm of western and Chinese traditional medicine are concerned. Western medicine stated that it′s pathogenesis is closely related to orexin and HLA-DQB1∗0602. In addition,recent studies from countries in Western Europe(UK,Finland,and Sweden)have indicated that the use of H1N1 influenza vaccine gives rise to incidence of the narcolepsy as well. From the realm of Chinese medicine,upsetting the balance of Yin-Yang and Yin-Wei are also possible causes attributed to the disease. In the case of child narcolepsy,the con-dition of the patient′s internal organs is also highly concerned.
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