Toll样受体与呼吸道感染性疾病的研究进展

摘要

Toll-like receptor,TLR (TLR) can sense invading pathogens,the acute inflammatory response in the body,chronic airway inflammation and pathophysiology of allergic diseases and play an important role in the immune defense response.Among them,TLR2,TLR4 most prominent role and become a hot research topic.This paper summarizes the importance of TLR2,TLR4 in the pathogenesis of respiratory tract infections,and pointed out by interfering with TLR2,TLR4 signal transduction pathway or reduced TLR2,TLR4g role may help to weaken the disease or improve the prognosis,which provides a new way of thinking and clues for the treatment of clinical common diseases.%Toll样受体(Toll-like receptor,TLR)参与机体急、慢性气道炎症反应以及过敏性疾病的病理生理过程,并在免疫防御反应中发挥重要作用.其中以TLR2、TLR4的作用最为突出而成为当前研究的热点.该文综述TLR2、TLR4在呼吸道感染性疾病的发病中的研究进展,指出通过干扰TLR2、TLR4的信号传导通路或者是减弱TLR2、TLR4的作用可能有助于减弱病情或改善预后,这为临床常见疾病的治疗提供了一个新的思路和线索.