IL-6/JAK/STAT3/SOCS3通路在炎症性肠病中的潜在治疗作用

摘要

在免疫和炎症反应中,IL-6是多效性的细胞因子,它通过激Janus激酶(Janus kinase,JAK)/信号转录与激活因子3(signal transducer and activator of transcription 3,STAT3)/细胞因子信号传导抑制因子3(suppressor of cytokine signaling3,SOCS3)起重要作用.而且,IL-6介导的JAK/STAT3/SOCS3信号通路的失调和炎症性肠病(inflammatory bowel disease,IBD)的形成密切相关.由此,IL-6/JAK/STAT3/SOCS3信号通路的调节受到广泛研究并用于寻找IBD的新的治疗方法.该文介绍IBD中IL-6/JAK/STAT3/SOCS3通路的作用机制和作用,描述目前的治疗方案并研究治疗IBD的潜在的治疗方案.%Interleukin-6(IL-6)is a pleiotropic cytokine with central roles in immune and inflammatory reactions through downstream activation of the Janus kinase 2/signal transducer and activator of transcription 3 /Suppressor of cytokine signaling3 ( JAK/STAT3/SOCS3 ) signaling pathway. Additionally, dysregulation of the interleukin( IL)-6-mediated JAK/STAT3/SOCS3 signaling pathway is closely related to the development of in-flammatory bowel disease( IBD) . On this basis,modulation of the IL-6/JAK/STAT3/SOCS3 signaling pathway is currently being widely explored to develop novel therapies for IBD. The present review details the mechanisms and roles of the IL-6/JAK/STAT3/SOCS3 pathway in IBD, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat IBD.