早产儿支气管肺发育不良的发病机制及治疗现状

摘要

支气管肺发育不良(bronchopulmonary dysplasia,BPD)的发病率居高不下,是婴儿期慢性肺疾病的首要原因.BPD的发病机制仍不是很清楚.目前研究认为BPD的危险因素包括:早产、肺发育不成熟、机械通气气压伤、容量伤、高氧暴露、感染以及继发过度炎症反应.近年来BPD与遗传因素的关系被相继报道.有研究证实上述危险因素参与BPD的发病过程,然而相对应的创新性治疗手段却少有报道.该文就新型BPD的发病机制及治疗现状作一综述.%The incidence of bronchopulmonary dysplasia is very high,and is still the major cause of chronic pulmonary disease in infancy.Although the mechanism is not completely clear.Recent studies have demonstrated that preterm delivery,immature lung development,postnatal injury from mechanical ventilation,oxygen exposure,infection and inflammatory response contribute to it.The association between BPD and genetics reported recently.However,relative therapeutic methods are rarely reported.This review summarizes the pathogenesis and therapy of BPD.