微小RNA-34家族与肺部疾病的研究进展

摘要

微小RNA(microRNA,miRNA)是一类长度约22个核苷酸的非编码单链小RNA,在转录后水平调控相关基因的表达,包括细胞增殖分化、凋亡及个体发育等.miR-34家族(miR-34s)是一组高度保守的miRNA家族,广泛存在于节肢动物、线虫纲动物及哺乳动物中.人源miR-34s包括miR-34a、miR-34b和miR-34c.大量研究显示,miR-34s与支气管肺发育不良、哮喘、慢性阻塞性肺部疾病、肺癌和肺动脉高压等肺部疾病的发生发展及转归有密切联系.该文将针对miR-34s与上述疾病的研究进展进行综述.%MicroRNA (miRNA) is a class of non-coding single-stranded small RNAs of about 22 nucleotides in length,which regulate the expression of related genes in post-transcriptional levels,including cell proliferation and differentiation,apoptosis and individual development.The miR-34 family (miR-34s) is a highly conserved microRNA family,which is widely found in arthropods,nematodes and mammals.Human miRNA-34s include miR-34a,miR-34b and miR-34c.A large number of studies have shown that miR-34s is closely related to the development and prognosis of pulmonary diseases,such as bronchopulmonary dysplasia,asthma,chronic obstructive pulmonary disease,lung cancer and pulmonary hypertension.This paper reviews the progresses of miR-34s and the diseases mentioned-above.