Objective: To investigate the clinicopathologic characteristics, diagnosis, treatment and prognosis of lymphangioma of duodenum.Methods: One case of lymphangioma at descending duodenum in adult was analyzed by means of gastroscopy and immunohistochemical examination with review of the 1iterature. Results:A 68-year-old female, presenting with abdominal discomfort, was diagnosed as duodenum lymphangioma. hTere was an irregular milky granular polypoid lesions in descending duodenum by gastroscopy. The pathological diagnosis was irregularly expanded lymphatics within intestinal muscular layer, of which the lumens contained lymph. Immunohistochemically, vascular epithelia were positive for D2-40, negative for CD34. Regular follow-up of patient, and endoscopic morphology did not change significantly after one year. Conclusion: Lymphangioma in descending duodenum is rare in adults. For patients with atypical symptoms of the upper abdomen, duodenal descending lesions should be considered the possibility of lymphangioma, and should be given individual treatment according to different clinical manifestations.%目的：探讨十二指肠淋巴管瘤的临床病理特点、诊断、治疗及预后。方法：1例上腹不适的患者除一般的血清学、尿液、腹部CT等检查外，接受胃镜检查并取粘膜行病理活检。结果：胃镜示十二指肠降部见不规则乳白色颗粒样隆起，病理示粘膜固有层见大小不一扩张的淋巴管，其腔内见淋巴液。免疫组化CD34阴性，D2-40阳性。患者定期随访，一年后内镜下形态未见明显改变。结论：十二指肠淋巴管瘤在成人中可能并不多见。对于上腹部不典型症状，十二指肠降部见隆起型病变的患者应考虑到淋巴管瘤的可能性。并根据不同临床表现个体化治疗。
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