Objective: To study the effects of propofol compound fentanyl target controlled infusion on bispectral index (BIS) in hypertension patients.Methods: Selected 105 hypertension patients with propofol compound fentanyl target controlled infusion anesthesia from January 2015 to March 2016 in our hospital, divided the patients into three groups according to the fentanyl concentration of target controlled infusion, concentration of 2.0 ng/mL for group I, 3.0 ng/mL for group II, and 4.0 ng/mL for group III, and target concentrations of propofol in three groups were all 4 μg/mL, each group of 35 patients. Compared the mean arterial pressure, heart rate at each time point and the change of the electrical double frequency index in the home 5 min (T0), before intubation (T1), 1 min atfer intubation (T2), 3 min atfer intubation (T3) and 5 min atfer intubation (T4) among three groups of patients, and compared their waking time.Results: hTe mean arterial pressure and heart rate of T2, T3 time point in group I were signiifcantly higher than that of T1 time points; in group II, mean arterial pressure and heart rate of T2 time were signiifcantly higher than that of T1 time points, the differences were statistically signiifcant (P<0.05); at T2, T3, and T4 point, the brain electrical double-frequency index in group III was obviously lower than that of group I and II, the difference was statistically signiifcant (P<0.05); waking time in group III was obviously longer than that of group I, II, the difference was statistically signiifcant (P<0.05).Conclusion: Using propofol compound fentanyl target controlled infusion to anesthetize hypertension patients, the bispectral index will decrease with the concentration of fentanyl, reduce intubation stress reaction, and maintain stable hemodynamics.%目的：研究丙泊酚复合瑞芬太尼靶控输注对高血压患者脑电双频指数的影响。方法：选择2015年1月至2016年3月在我院行丙泊酚复合瑞芬太尼靶控输注麻醉的高血压患者105例，根据使用瑞芬太尼靶控输注的浓度将患者分为3组，Ⅰ组浓度为2.0 ng/mL、Ⅱ组浓度为3.0 ng/mL、Ⅲ组浓度为4.0 ng/mL，其三组丙泊酚的靶浓度均为4μg/mL，每组各35例患者。观察比较三组患者在入室5 min(T0)、插管前(T1)、插管后1 min(T2)、插管后3 min(T3)以及插管后5 min(T4)各时间点的平均动脉压、心率以及脑电双频指数的变化，并比较其苏醒的时间。结果：Ⅰ组患者在T2、T3时间点的平均动脉压与心率均明显的高于T1时间点，Ⅱ组患者在T2时间点的平均动脉压与心率均明显的高于T1时间点，比较差异具体统计学意义(P<0.05)；在T2、T3与T4时间点上，Ⅲ组患者的脑电双频指数明显的低于Ⅱ组患者与Ⅰ组患者，比较差异具有统计学意义(P<0.05)；Ⅲ组患者的苏醒时间明显的长于Ⅰ组、Ⅱ组患者，比较差异显著(P<0.05)。结论：使用丙泊酚复合瑞芬太尼靶控输注麻醉高血压患者，其脑电双频指数会随着瑞芬太尼的浓度而降低，减低插管应激反应，并能够维持血流动力学的平稳。
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