心脏死亡捐献供肝热缺血再灌注损伤及MRI评价的研究进展

摘要

供体严重短缺是制约我国肝移植事业发展的瓶颈，而心脏死亡捐献（DCD）将有效扩大供体来源，但肝脏热缺血再灌注损伤一直困扰着DCD供肝的利用效果。功能MR成像能够无创、准确评价活体肝组织的微观信息变化，并获得动态的定量资料，对进一步认识肝脏热缺血再灌注损伤的机制及其预后评估提供有价值的信息。现就我国DCD供肝现状、肝脏热缺血再灌注损伤及MRI评价予以综述。%Donor shortage has hampered the development of liver transplantation in China. Donation after Cardiac Death (DCD) will effectively expand the donor source, while hepatic warm ischemia-reperfusion injury has severe influence on the prognosis of DCD liver graft. Functional MR imaging can evaluate microscopic information changes of liver tissue in vivo non-invasively, accurately and quantitatively, the results are expected to provide valuable information on further understanding the mechanism and prognosis of hepatic warm ischemia-reperfusion injury. The aims of the present review were as follows: (a) to present the state of DCD donor liver in China, (b) to present the hepatic warm ischemia-reperfusion injury, and (c) to review the MRI evaluation of hepatic warm ischemia-reperfusion injury.