非贫血性地中海贫血患者红细胞和网织红细胞参数的分析

摘要

Objective To explore the changes of erythrocyte and reticulocyte parameters and their clinical significance in patients with non-anemia thalassemia.Methods Beckman Coulter LH-750 Automated Blood Cell Counter was applied to measuring erythrocyte and reticulocyte counting in 100 healthy adults and 100 patients with non-anemia thalassemia;and the test results were statistically analyzed.Results In patients with non-anemia thalassemia,the levels of RBC,red cell distribution width(RDW),RET# and HLR# increased markedly;hemoglobin(Hb),mean corpuscular volume(MCV),mean corpuscular hemoglobin(MCH),mean reticulocyte volume(MRV),and mean spherocyte volume(MSCV)decreased markedly,while RET%,HLR% and IRF had no significant changes.Conclusion Screening of non-anemia thalassemia by routine hematological examination has the vital clinical significance in clinical diagnosis and aristogenesis.%目的 探讨非贫血性地中海贫血患者红细胞及网织红细胞参数的变化及临床意义.方法 应用Beckman Coulter公司的LH-750型全自动血细胞分析仪,检测100例非贫血性地中海贫血患者和100例健康成人的红细胞和网织红细胞参数,对所得数据进行统计学分析.结果 非贫血性地中海贫血患者红细胞、红细胞体积分布宽度、网织红细胞绝对值、高光散网织红细胞绝对值增高,血红蛋白、平均红细胞体积、平均红细胞血红蛋白量、平均网织红细胞体积、平均球形细胞体积显著降低,网织红细胞百分率、高光散网织红细胞百分率、未成熟网织红细胞指数变化不大.结论 血常规筛查出非贫血性地中海贫血患者对临床和优生优育有重要的意义.