定量检测N末端脑钠肽对心衰的诊断价值

摘要

Objective To evaluate the diagnostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) quantitative detection in patients with heart failure.Methods Quantitative enzyme-linked immunosorbent assay (ELISA) improvement method was applied to measuring serum level of NT-proBNP in patients with different degree of heart failure.Results The serum level of NT-proBNP was significantly elevated in patients with heart failure. With the increase of extent of heart failure, NT-proBNP increased in exponent. Receiver operator characteristic curve (ROC) showed that area under curve (AUC) was 0.898. The sensitivity and specificity were 91.9% and 92.3% respectively for diagnosis of heart failure.Conclusion Quantitative detection of NT-proBNP is at present the best laboratory test for evaluating heart function of patients with heart failure.%目的 评价血清N末端脑钠肽(NT-proBNP)定量检测对心力衰竭患者的诊断价值.方法 采用定量ELISA改进法检测不同心衰程度的患者血清NT-proBNP.结果 心衰患者血清NT-proBNP水平明显增高,并随心衰患者程度加重呈指数增加;实验受试者工作特征曲线下面积为0.898;心衰的诊断敏感性和特异性分别为91.9%和92.3%.结论 定量检测血清NT-proBNP是目前用于评价心衰患者的最佳实验手段.