多肿瘤标志物蛋白芯片检测技术对卵巢癌的诊断价值分析

摘要

目的 探讨多肿瘤标志物蛋白芯片检测技术对卵巢癌的诊断价值.方法 采用多肿瘤标志物蛋白芯片检测系统,测定卵巢癌患者、良性卵巢疾病患者和健康人血清中的12种肿瘤标志物的水平.结果 卵巢癌组的糖链抗原125(CA125)、癌胚抗原(CEA)、糖链抗原242(CA242)和糖链抗原199(CA199)的血清水平高于其他两组,差异有统计学意义(P<0.01);CA125单指标的诊断灵敏度、特异性和准确度高于其他肿瘤标志物,联合检测可提高对卵巢癌的诊断.结论 多肿瘤标志物联合检测对卵巢癌诊断和鉴别诊断有较高灵敏度、特异性和准确度,对于初步判断卵巢病变有一定的帮助.%Objective To investigate the diagnostic values of multiple tumor markers protein biochip for ovarian cancer. Methods Serum levels of 12 tumor markers were evaluated by tumor markers protein biochip for patients with ovarian cancer(ovarian cancer group) , patients with benign ovarian diseases and healthy women as controls. Results The serum levels of CA125,Ferritin,CEA and CA242 in ovarian cancer group were significantly higher than those of the other two groups (P<0. 01). The diagnostic sensitivity, specificity and accuracy of CA125 were higher than other markers,and combined detection could improve the diagnostic positive rate of ovarian cancer. Conclusion The combined detection of multiple tumor markers was with relative higher sensitivity,specificity and accuracy for the diagnosis and differential diagnosis of ovarian cancer,and could be helpful of the assessment of pathological changes of ovarian.