急性冠脉综合征患者血清MMP-2与Hcy检测临床意义分析

摘要

目的 探讨基质金属蛋白酶-2(MMP-2)及同型半胱氨酸(Hcy)在急性冠脉综合征(ACS)中的临床价值.方法 选取ACS确诊患者72例,其中急性心肌梗死(AMI)37例、不稳定型心绞痛(UA)35例,以28例健康者作为对照.分别采用酶联免疫吸附法和循环酶法检测血清MMP-2和Hcy水平.结果 AMI组和UA组MMP-2和Hcy浓度均高于对照组,且AMI组高于UA组(P<0.05).AMI组急性期及恢复期MMP-2、Hcy水平也存在统计学差异(P<0.05).结论 ACS患者血清MMP-2和Hcy水平与冠脉损伤有一定相关性,可作为ACS诊断和预后判断的指标.%Objective To study the clinical significance matrix metalloproteinase-2(MMP-2) and homocysteine(Hcy) in patients with acute coronary syndrome(ACS). Methods 72 cases of patients with ACS,including 37 cases with acute myocardial infarction (AMI) and 35 cases with unstable angina(UA) ,and 28 cases of healthy subjects (control group) were enrolled and detected for ser-um levels of MMP-2 and Hey. Results MMP-2 and Hey levels in AMI group and UA group were higher than control group, and those of AMI group were higher in UA group(P＜ 0. 05). MMP-2 and Hcy levels in AMI patients at acute stage and remission stage were with significant difference(P＜ 0. 05). Conclusion Serum levels of MMP-2 and Hcy might be correlated with the coronary damage in patients with ACS, which could be used for the diagnosis and prognosis of ACS.