同型半胱氨酸和超敏C反应蛋白在急性冠脉综合征危险分层中的应用

摘要

Objective To discuss the application of plasma homocysteine(Hcy) and high-sensitivity C-reactive protein(hs-CRP) levels in risk stratification of acute coronary syndrome(ACS).Methods 71 patients with ACS were included in disease group and subjected to risk stratification according to GRACE risk score software.Another89 healthy people who had undergone physical examination served as health control group.Their plasma Hcy and hs-CRP were detected.Results Differences of plasma Hcy between each group of risk stratification and health control group demonstrated statistical significance(P＜0.05),while there was no statistically significant difference among risk stratification groups(P＞0.05).Differences of plasma hs-CRP between health control group and midium risk group or high risk group showed statistical significance(P＜0.05),while there were no statistical significant differences in low risk group and the health control group,midium risk group and high risk group(P＞0.05).Compared with high and low risk groups or low and midium risk groups,the differences between them were found to be statistically significant(P＜0.05).Conclusion Hcy and hs-CRP detection both possess certain referential meaning in early diagnosis.Hs-CRP level may indicate risk degree of disease.However,Hcy currently shows no obvious significance in this respect and further thorough research should be undertaken.%目的 探讨血浆同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平在急性冠脉综合征(ACS)危险分层中的应用.方法 病例组选取ACS患者71例,并按GRACE危险评分软件对其进行危险分层,另选取体检健康者89例作为健康对照组,检测Hcy和hs-CRP.结果 Hcy在各危险分层组与健康对照组之间差异均有统计学意义(P＜0.05),但在各危险分层之间差异均无统计学意义(P＞0.05)；hs-CRP在中危组、高危组与健康对照组差异有统计学意义(P＜0.05),低危组与健康对照组、中危组与高危组的差异无统计学意义(P＞0.05),高危组与低危组、低危组与中危组的差异有统计学意义(P＜0.05).结论 Hcy和hs-CRP的检测在ACS的早期诊断中均具有一定参考意义,hs-CRP水平可以提示患者疾病的危险程度,但Hcy目前在此方面暂无显著的意义,仍需进一步深入的研究.