目的：探讨血清特异性IgE（sIgE）和特异性IgG4（sIgG4）检测在儿童过敏性哮喘及过敏性鼻炎中的临床应用价值。方法采用ELISA法对85例过敏性哮喘组患儿、72例过敏性鼻炎组患儿及60例对照组健康儿童血清中sIgE和sIgG4进行检测。采用ROC曲线分析sIgE和sIgG4对过敏性哮喘和过敏性鼻炎的诊断效能。结果过敏性哮喘组和过敏性鼻炎组治疗前血清sIgE和sIgG4水平均明显高于对照组，差异有统计学意义（P＜0．01）。治疗6个月后，过敏性哮喘组及过敏性鼻炎组血清sIgE水平均较治疗前有明显下降，而血清sIgG4水平却较治疗前明显上升，差异均有统计学意义（P＜0．01）。sIgE和sIgG4联合检测，对过敏性哮喘和过敏性鼻炎的诊断灵敏度分别为90．6％（77/85）和84．7％（61/72），诊断特异度分别为81．2％（69/85）和76．4％（55/72）。结论sIgE和sIgG4是反映过敏性疾病的良好指标。%Objective To explore the clinical application value of the detection of sIgE and sIgG4 in children with allergic asthma and allergic rhinitis .Methods The levels of sIgE and sIgG4 of allergic asthma group (n=85) ,allergic rhinitis group (n=72) and control group (n=60) were respectively detected by ELISA .The diagnostic efficiency of sIgE and sIgG4 were analyzed by using ROC curve .Results Before treatment ,the serum levels of sIgE and sIgG4 of allergic asthma group and allergic rhinitis group were remarkably higher than those of control group (P< 0 .01) .After 6 -month treatment ,the serum sIgE levels of allergic asthma group and allergic rhinitis group significantly decreased ,and the serum sIgG4 levels significantly increased (P< 0 .01) .For the combined detection of sIgE and sIgG4 ,the diagnostic sensitivities of allergic asthma and allergic rhinitis were 90 .6% (77/85) and 84 .7% (61/72) respectively ,and the diagnostic specificities of allergic asthma and allergic rhinitis were 81 .2% (69/85) and 76 .4%(55/72) respectively .Conclusion The serum sIgE and sIgG4 are good indicators for the diagnosis of allergic diseases .
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