高效抗逆转录病毒联合抗免疫治疗对艾滋病合并肺结核患者的影响

摘要

Objective To study the influence of highly efficient antiretrovirus combined with anti-immune therapy on the im-mune function and metabolism in the patients with AIDS complicating pulmonary tuberculosis (TB) .Methods 170 patients with AIDS complicating pulmonary TB from May 2013 to May 2013 were selected and divided into the observation group and control group according to the random number table method ,85 cases in each group .The control group was given highly efficient antiretro-virus and conventional anti-TB medication therapy ,while on this basis the observation group was combined with anti-immune thera-py .Then the indicators of immune function ,lipid metabolism ,toxic and side reactions were compared between two groups .Results The CD4+ and CD4/CD8+ levels after 6-month treatment in the observation group were significantly higher than those in the con-trol group(P<0 .05) ,the CD8+ level was significantly lower than that in the control group(P<0 .01);Serum total cholesterol ,tria-cylglycerol and low density lipoprotein cholesterol levels in the observation group were significantly lower than those in the control group(P<0 .05) ,the high density lipoprotein cholesterol level was significantly higher than that in the control group (P<0 .01);the occurrence rate of toxic reactions and side effects such as nausea and vomiting in the observation group was 14 .12% ,which was significantly lower than 27 .06% in the control group(χ2 =4 .353 ,P<0 .05) .Conclusion Highly efficient antiretrovirus combined with anti-immune therapy is conducive to improve the immune function in the patients with AIDS complicating pulmonary TB ,de-creases its influence on the body metabolism ,and reduces the digestive tract reactions such as nausea and vomiting .%目的 探讨高效抗逆转录病毒联合抗免疫治疗对艾滋病合并肺结核患者机体免疫功能及代谢的影响.方法 选取2013年5月至2016年5月收治的艾滋病合并肺结核患者170例,采用随机数字表法分为观察组和对照组,每组各85例.对照组采用高效抗逆转录病毒及常规抗结核药物进行治疗,观察组在对照组基础上联合抗免疫治疗,比较两组免疫功能、脂代谢和毒副反应等指标.结果 治疗6个月后,观察组CD4+、CD4/CD8+水平明显高于对照组(P<0.05),CD8+水平明显低于对照组(P<0.01);血清总胆固醇、三酰甘油和低密度脂蛋白胆固醇水平明显低于对照组(P<0.05),高密度脂蛋白胆固醇水平明显高于对照组(P<0.01);恶心呕吐等毒副反应率为14.12%,明显低于对照组的27.06%(χ2=4.353,P<0.05).结论 高效抗逆转录病毒联合抗免疫治疗有助于改善艾滋病合并肺结核患者的免疫功能,降低对机体代谢的影响,减少恶心呕吐等消化道反应.