Objective To analyze the relationship between anti Mullerian hormone (AMH) levels and abnormal endocrine metab-olism in patients with polycystic ovary syndrome (PCOS) .Methods From January 2014 to December 2015 ,a total of 200 PCOS pa-tients were recruited into experimental group ,180 infertility patients causing by tubal disorder were selected into the control group . According to the level of AMH ,PCOS patients were divided into high AHM group(AMH=10 ng/mL ,98 cases) and low AMH group (AMH<10 ng/mL ,102 cases) .According to the index of insulin resistance(HOMA) ,PCOS patients were divided into high HOMA group(HOMA index=2 .97 ,108 cases) ,and low HOMA group (HOMA index <2 .97 ,92 cases) .Follicle stimulating hor-mone(FSH) ,serum AMH ,estradiol ,luteinizing hormone(LH) ,fasting blood glucose and fasting insulin ,testosterone(T) ,high den-sity lipoprotein(HDL) ,low density lipoprotein(LDL) were detected ,the level of insulin resistance(factor HOMA-IR were calculat-ed ,then internal secretion metabolic differences and the effect of AMH were analyzed .Results The AMH ,HOMA-IR ,LH ,T in the control group were significantly lower than those in the experimental group(P<0 .05) ,body mass index(BMI) in the control group was significantly higher than that in the experimental group(P<0 .05) .BMI ,HOMA-IR in the high AMH group were sig-nificantly lower than those in the low AMH group(P<0 .05) .There were no significant differences on LH and T between the high AMH group and low AMH group (P>0 .05) .AMH ,INS ,BMI in the high AMH group were higher than those in the low AMH group(P<0 .05) .Conclusion AMH in patients with PCOS increased significantly ,and AMH was negatively correlated with BMI and HOMA-IR ,and positively correlated with testosterone .%目的 分析抗苗勒管激素(AMH)水平在多囊卵巢综合征(PCOS)患者中与内分泌代谢异常之间的关系.方法 选取2014年1月至2015年12月临床上确诊为PCOS的200例患者为试验组,以及同期因输卵管因素不孕的180例患者作为对照组,试验组据AMH水平分为高AHM组(AMH≥10 ng/mL,n=98)和低AMH组(AMH<10 ng/mL,n=102);将根据稳态模型胰岛素抵抗指数(HOMA-IR)分为高HOMA-IR组(HOMA-IR≥2.97,n=108)和低HOMA-IR组(HOMA-IR<2.97,n=92).测定各组卵泡刺激素(FSH)、AMH、雌二醇(E2)、黄体生成素(LH)、空腹血糖(FPG)、空腹胰岛素(INS)、睾酮(T)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL),计算HOMA-IR,比较各组内分泌代谢指标差异,分析AMH水平的影响因素.结果 对照组AMH、HOMA-IR、LH、T均显著低于试验组(P<0.05),体质量指数(BMI)高于试验组(P<0.05).高AMH组BMI、HOMA-IR均显著低于低AMH组(P<0.05).高HOMA-IR组与低HOMA-IR组间LH和T水平差异均无统计学意义(P>0.05),高HOMA-IR组AMH、INS、BMI水平均显著高于低HOMA-IR组,差异有统计学意义(P<0.05).结论 PCOS患者AMH显著升高,且AMH与BMI、HOMA-IR负相关,与T呈正相关.
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