生殖道衣原体感染与IL-2、IL-6及血清抗衣原体免疫优势蛋白抗体检出率的关系

摘要

目的 探讨白细胞介素-2(IL-2)、IL-6及血清抗衣原体免疫优势蛋白抗体检出率在生殖道衣原体感染患者中的变化.方法 选取2016年1月至2016年5月该院确诊的60例生殖道衣原体感染妇女(CT组)、60例健康妇女(对照组),分别检测两组血清IL-2、IL-6、抗衣原体免疫优势蛋白及宫颈分泌物中的IL-2、IL-6.结果 CT组患者的血清及宫颈分泌物中IL-2、IL-6检测水平均显著的高于对照组,差异具有统计学意义(P<0.05);CT组患者的血清抗外膜蛋白复合物B蛋白C端肽(OmcBc)抗体、抗衣原体质粒偏码蛋白3(Pgp3)抗体、抗热休克蛋白60(HSP60)抗体、抗比841编码蛋白(CTT841)抗体阳性检出率分别为45.00%、75.00%、23.33%、38.33%均显著高于对照组,差异具有统计学意义(P<0.05).结论 生殖道衣原体感染患者IL-2、IL-6及血清抗衣原体免疫优势蛋白抗体阳性检出率显著升高,对于临床诊断及治疗具有一定的指导意义.%Objective To investigate the changes of detection rates of IL-2,IL-6 and serum anti-Chlamydia immunodominant protein antibody in the patients with Chlamydia trachomatis genital tract infection.Methods Sixty women with genital tract infection (CT group) and 60 healthy women (control group) were selected in our hospital from January to May 2016.The serum levels of IL-2,IL-6 and anti-Chlamydia immunodominant protein and IL-2 and IL-6 levels in cervical secretions were detected in the two groups.Results The IL-2 and IL-6 levels of serum and cervical secretions in the CT group were significantly higher than those in the control group,the difference was statistically significant (P<0.05);the positive detection rates of serum OmcBc antibody,Pgp3 antibody,HSP60 antibody and CTT841 antibody in the CT group were 45.00%,75.00%,23.33% and 38.33% respectively,which were significantly higher than those in the control group,the difference was statistically significant (P<0.05).Conclusion The positive detection rates of IL-2,IL-6 and serum anti-Chlamydia immunodominant protein antibody in the patients with genital tract Chlamydia infection are significantly increased,which has some guiding significance for clinical diagnosis and treatment.