异甘草酸镁对胃肠道肿瘤化疗患者肝功能的保护作用研究

摘要

目的 分析异甘草酸镁对胃肠道肿瘤化疗患者的肝功能保护作用.方法 于2012年4月至2015年12月,将168例胃肠道肿瘤化疗患者随机分为观察组和对照组,每组各84例.观察组患者给予异甘草酸镁治疗,对照组患者给予谷胱甘肽治疗.同时将观察组分为观察A组和观察B组,每组各24例;将对照组分为对照A组和对照B组,每组各24例.观察A组、对照A组患者按5-氟尿嘧啶联合奥沙利铂(FOLFOX4)方案治疗.观察B组、对照B组按卡培他滨联合奥沙利铂(XELOX)方案治疗.比较各组患者治疗后肝功能异常发生情况及治疗前后肝功能指标变化情况.结果 经相应治疗后,观察组患者肝功能异常总发生率低于对照组(P<0.05);观察组和对照组肝功能指标水平均较治疗前明显提高(P<0.05),且对照组治疗后肝功能指标水平明显高于观察组(P<0.05);观察A组与对照A组肝功能指标水平均较治疗前明显提高(P<0.05),且对照A组治疗后肝功能指标水平高于观察A组(P<0.05);观察B组与对照B组肝功能指标水平均较治疗前明显提高(P<0.05),且对照B组治疗后肝功能指标水平高于观察B组(P<0.05).结论 异甘草酸镁对胃肠道肿瘤化疗患者肝功能的保护效果较佳,可明显改善患者肝功能,值得临床推广应用.%Objective To investigate the effects of magnesium isoglycyrrhizinate on liver function of patients with gastrointestinal cancer following chemotherapy.Methods From Apr.2012 to Dec.2015,a total of 168 cases of patients with gastrointestinal cancer following chemotherapy were enrolled,and were randomly divided into observation group(84 cases) and control group(84 cases).Each of the two groups was divided into A group(42 cases) and B group(42 cases) according to the treatment methods.Patients of observation group(including observation A group and observation B group) were treated with magnesium isoglycyrrhizinate,while patients of control group(including control A group and control B group) were treated with glutathione.Patients of A group(including observation A group and control A group) were treated with FOLFOX4 regimen,while patients of B group(including observation B group and control B group) were treated with XELOX regimen.The incidence of abnormal liver function and changes of the levels of liver function of each group were analyzed and compared.Results After the appropriate treatment,the abnormal rate of liver function of observation group were significantly lower than control group(P<0.05).After treatment,levels of liver function parameters in observation group and control group were all significantly increased(P<0.05),and those in control group were higher than observation group(P<0.05).After treatment,levels of liver function parameters in observation A group and control A group were all significantly increased(P<0.05),and those in control A group were higher than observation A group(P<0.05).After treatment,levels of liver function parameters in observation B group and control B group were all significantly increased(P<0.05),and those in control B group were higher than observation B group(P<0.05).Conclusion Magnesium isoglycyrrhizinate could be with protection effects on liver function of patients with gastrointestinal cancer following chemotherapy,which might be worthy of promotion.