老年脑卒中患者围治疗期血清同型半胱氨酸及血脂水平变化的分析

摘要

目的 探讨老年脑卒中患者围治疗期血同型半胱氨酸(Hcy)及血脂水平变化的临床意义.方法 选取2015年6月至2016年12月该院71例老年脑卒中患者和50例健康体检者分别作为观察组和对照组,观察组口服辛伐他汀和阿司匹林治疗,检测两组血清 Hcy和高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)水平,并对检测结果进行统计分析.结果 观察组治疗前血清Hcy水平高于对照组,差异有统计学意义(P<0.05);观察组治疗前HDL-C、TG、TC水平高于对照组,而HDL-C水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后血清 Hcy 水平低于治疗后,差异有统计学意义(P<0.05);观察组治疗后 HDL-C、TG、TC水平低于治疗前,而 HDL-C水平高于治疗前,差异有统计学意义(P<0.05).结论 血清 Hcy及血脂各项指标可作为老年脑卒中诊断和疗效观察的辅助指标.%Objective To investigate the changes of serum homocysteine(Hcy)and blood lipid levels during perioperative period in elderly patients with stroke.Methods A total of 71 elderly patients with stroke and 50 healthy people undergoing physical examination in this hospital from June 2015 to December 2016 were select-ed as the observation group and control group respectively.T he observation orally took simvastatin and aspi-rin.The levels of Hcy,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),three acylglycerol(TG)and total cholesterol(TC)were detected in the two groups.The detection results were statistically analyzed.Results The serum Hcy level before treatment in the observation group was high-er than that in the control group,the difference was statistically significant(P<0.05);the levels of HDL-C, TG,TC before treatment in the observation group were higher than those in the control group,while the HDL-C level was lower than that in the control group,the difference was statistically significant(P<0.05);the serum Hcy level after treatment in the observation group was lower than that before treatment,the differ-ence was statistically significant(P<0.05);the levels of LDL-C,TG and TC after treatment in the observation group were lower than those before treatment,while the HDL-C level was higher than that before treatment, the difference was statistically significant(P< 0.05).Conclusion Serum Hcy and blood lipid indicators can serve as the assisted indicators of diagnosis and effect judgment of senile stroke.