宫颈癌患者血清中肿瘤标志物检测的价值研究

摘要

Objective To investigate the value of serum tumor marker detection in the patients with cervi-cal cancer.Methods 97 patients with cervical cancer in this hospital from January 2015 to December 2016 were selected as the observation group and 47 healthy women undergoing physical examination were selected as the control group.The levels of serum squamous cell carcinoma antigen(SCC-Ag),carbohydrate antigen 125(CA125)and carcinoembryonic antigen(CEA)were determined in the two groups.Then the results were statistically analyzed.Results The levels of serum SCC-Ag,CA125 and CEA in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05);the serum SCC-Ag level in the patients with aquamous carcinoma was higher than that in the patients with adenocarcinoma, while the levels of serum CA125 and CEA were lower than those in the patients with adenocarcinoma,the difference was statistically significant(P< 0.05);serum SCC-Ag,CA125 and CEA levels in the stage Ⅲ-Ⅳwere significantly higher than those in the stage Ⅰ and Ⅱ,moreover serum SCC-Ag,CA125 and CEA levels in the stage Ⅱ were significantly higher than those in the stage Ⅰ,the difference was statistically significant (P<0.05);serum SCC-Ag,CA125 and CEA levels in the patients with low differentiation were significantly higher than those in the patients with high differentiation,the difference was statistically significant(P<0.05).Conclusion The detection of serum SCC-Ag,CA125 and CEA is conducive to early diagnose cervical cancer,moreover their combined detection can increase the sensitivity and specificity of diagnosis.%目的 探讨宫颈癌患者血清肿瘤标志物检测的临床价值.方法 选取2015年1月至2016年12月该院收治的宫颈癌患者97例和健康体检女性47例分别作为观察组和对照组,检测两组血清鳞状细胞癌抗原(SCC-Ag)、糖链抗原125(CA125)和癌胚抗原(CEA),并对结果进行统计分析.结果 观察组血清SCC-Ag、CA125、CEA水平高于对照组,差异有统计学意义(P<0.05);鳞癌患者血清SCC-Ag水平高于腺癌患者,而CA125和CEA水平低于腺癌患者,差异有统计学意义(P<0.05);Ⅲ ~ Ⅳ期患者血清SCC-Ag、CA125和CEA水平明显高于Ⅰ期、Ⅱ期患者,且Ⅱ期患者血清SCC-Ag、CA125和CEA水平明显高于Ⅰ期患者,差异均有统计学意义(P<0.05);低分化患者血清SCC-Ag、CA125、CEA 水平明显高于中高分化患者,差异有统计学意义(P<0.05).结论 血清SCC-Ag、CA125、CEA检测有助于早期诊断宫颈癌,且它们联合检测能够提高诊断的灵敏度和特异度.